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目的探求控制耐甲氧西林金黄色葡萄球菌(MRSA)感染的抗菌药应用现状,以利于指导临床合理用药。方法对79例确认病例进行用药全程的回顾性分析;统计各品种对MRSA的敏感度及不同时段的用药频度变化。结果79例MRSA感染病例,涉及用药35种,平均每例用药24.5d、6.65种、药费10840元。药敏试验前使用对MRSA敏感品种不足40%,但却占用药天数和品种数的70%。药敏结果报告后,用药准确率可达90%以上。万古霉素类仍为目前对MRSA最敏感(100%)和使用最多(55%)的品种。结论及早进行MRSA的分离确认和药敏试验,对缩短疗程、节省抗生素资源及药费,均有积极的指导意义。
Objective To explore the application status of antibacterials for controlling methicillin-resistant Staphylococcus aureus (MRSA) infection in order to guide clinical rational drug use. Methods A total of 79 confirmed cases were retrospectively analyzed. The sensitivity of each species to MRSA and the change of medication frequency in different periods were calculated. Results 79 cases of MRSA infection, involving 35 kinds of medication, the average medication for each 24.5d, 6.65 kinds, drug costs 10,840 yuan. Less than 40% of the MRSA-susceptible varieties were used prior to the drug susceptibility test but accounted for 70% of the day and variety of the drug. Drug susceptibility results reported, the drug accuracy rate of up to 90%. Vancomycin remains the most current (100%) and most used (55%) varieties of MRSA at present. Conclusions As soon as possible, MRSA separation and drug susceptibility testing can be instructive in shortening the course of treatment, saving antibiotics resources and medical expenses.