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目的 观察和分析血清25羟基维生素D3〔25(OH)D3〕水平与冠状动脉病变严重程度的相关性。方法 选择性冠状动脉造影（CAG）诊断的冠心病患者234例；按25(OH)D3水平分为2组：25(OH)D3非缺乏组〔25(OH)D3≥20 ng/ml，n=33〕和25(OH)D3缺乏组〔25(OH)D3<20 ng/ml,n=201〕。冠状动脉狭窄程度采取国际通用的Gensini评分系统积分；全自动生化分析仪测定空腹血糖（FPG）、总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C），采用串联质谱法检测25(OH)D3。结果 25（OH)D3缺乏组的冠脉病变支数及Gensini积分均显著高于非缺乏组(P<0.05)。Logistic回归分析显示年龄、FPG及25(OH)D3水平是冠脉病变的独立相关因素。Gensini积分与年龄、FPG、LDL-C及TC呈正相关，与25(OH)D3水平呈负相关。结论 25(OH)D3水平是冠心病冠脉病变严重程度的相关因素，二者呈负相关。
Objective To observe and analyze the correlation between serum 25-hydroxyvitamin D3 (25 (OH) D3) and the severity of coronary artery disease. Methods 234 patients with coronary artery disease diagnosed by selective coronary angiography (CAG) were divided into two groups according to the level of 25 (OH) D3: 25 (OH) D3 non-deficient group (25 (OH) = 33] and 25 (OH) D3 deficient group [25 (OH) D3 & lt; 20 ng / ml, n = 201]. The degree of coronary artery stenosis was determined by Gensini scoring system. The automatic biochemical analyzer was used to measure the levels of fasting blood glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL- Density lipoprotein cholesterol (LDL-C), 25 (OH) D3 was detected by tandem mass spectrometry. Results The number of coronary lesions and Gensini scores in 25 (OH) D3-deficient group were significantly higher than those in non-deficient group (P <0.05). Logistic regression analysis showed that age, FPG and 25 (OH) D3 levels were independent correlates of coronary artery disease. Gensini score was positively correlated with age, FPG, LDL-C and TC, but negatively correlated with 25 (OH) D3. Conclusion 25 (OH) D3 level is a correlative factor of the severity of coronary artery disease in coronary heart disease, and the two are negatively correlated.