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目的 探讨胰岛素样生长因子Ⅰ（ＩＧＦⅠ） 及其受体（ＩＧＦⅠＲ）在肝细胞癌变过程中的作用及意义．方法 采用ＤＮＡＲＮＡ 原位杂交方法观察肝癌（ ｎ ＝ ３０） 和癌旁肝组织中ＩＧＦⅠ，ＩＧＦⅠ受体ｍ ＲＮＡ 的表达．结果 在肝癌和癌旁肝组织中ＩＧＦⅠ的表达率分别为４０－０ ％和５０－０ ％ ，ＩＧＦⅠ受体的表达率分别为４６－７ ％ 和５３－３ ％ ；ＩＧＦⅠ，ＩＧＦⅠ受体在分化较差的癌细胞和不典型增生肝细胞中表达最为明显．结论 ＩＧＦⅠ和ＩＧＦⅠ受体可能在肝细胞癌变过程中发挥重要作用．
Objective To investigate the role and significance of insulin-like growth factor I (IGF-I) and its receptor (IGF-IR) in hepatocellular carcinogenesis. Methods DNA-RNA in situ hybridization was used to observe the expression of IGF-I and IGF-I receptor m RNA in liver cancer (n = 30) and adjacent liver tissues. Results The expression rates of IGF-I in hepatocellular carcinoma and adjacent liver tissues were 40-50 % and 50- 0 % respectively, and the expression rates of IGF-I receptors were 46-7 % and 53-3 % respectively; IGF-I The expression of IGF-I receptor was most obvious in poorly differentiated cancer cells and dysplasia liver cells. Conclusion IGFI and IGFI receptors may play an important role in hepatocellular carcinogenesis.