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骨髓间充质干细胞(MSC)具有在体内和体外支持造血的功能,因此联合 MSC 的造血干细胞移植有可能增强移植效果,最近研究结果证实联合 MSC的造血干细胞移植可以促进造血干细胞的植入和造血恢复。既往研究发现急性白血病患者骨髓造血微环境存在病理改变,包括细胞的组成和功能改
Bone marrow-derived mesenchymal stem cells (MSCs) have the function of supporting hematopoiesis in vivo and in vitro. Therefore, transplantation of hematopoietic stem cells combined with MSCs may enhance the transplanting effect. Recent results confirmed that transplantation of hematopoietic stem cells in combination with MSCs can promote hematopoietic stem cell transplantation and hematopoiesis restore. Previous studies found that pathological changes of bone marrow microenvironment in patients with acute leukemia, including changes in cell composition and function