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目的研究分析慢性乙型肝炎患者血清免疫球蛋白水平变化情况,探讨其临床诊治指导意义。方法选取我院2011年10月—2013年5月间收治的140例慢性乙型肝炎患者进行检验分析,将70例慢性重型乙型肝炎患者组成观察A组,70例慢性乙型肝炎患者组成观察B组,选取同时期我院70例健康体检者组成对照组,对比分析3组患者IgG、IgA、IgM水平。根据患者治疗情况将患者分为好转组与未好转组,对比两组免疫球蛋白、总胆红素及凝血酶原活动度水平。两组对比P<0.05有显著性差异。结果观察A组与B组免疫球蛋白水平显著高于对照组(P<0.01),且观察A组水平显著高于观察B组(P<0.01)。好转组免疫球蛋白、总胆红素及凝血酶原活动度显著低于未好转组(P<0.01)。结论免疫球蛋白是乙型肝炎临床诊治中重要指标,临床检验对患者病情判断有重要指导意义,同时总胆红素与凝血酶原活动度检验在乙型肝炎临床诊治中应用价值显著。
Objective To study the changes of serum immunoglobulin levels in patients with chronic hepatitis B and to discuss its clinical significance. Methods A total of 140 patients with chronic hepatitis B admitted to our hospital from October 2011 to May 2013 were selected and analyzed. The composition of 70 patients with chronic severe hepatitis B and the 70 patients with chronic hepatitis B were observed. Group B, select the same period 70 cases of healthy subjects in our control group, comparative analysis of three groups of patients IgG, IgA, IgM levels. According to the patient’s treatment, the patients were divided into improvement group and non-improvement group. The levels of immunoglobulin, total bilirubin and prothrombin were compared. There was a significant difference between the two groups (P <0.05). Results The level of immunoglobulin in group A and group B was significantly higher than that in control group (P <0.01), and the level in group A was significantly higher than that in group B (P <0.01). The activity of immunoglobulin, total bilirubin and prothrombin in recuperation group was significantly lower than that in remission group (P <0.01). Conclusion Immunoglobulin is an important indicator in the clinical diagnosis and treatment of hepatitis B. The clinical test has important guiding significance for judging the patient’s condition. At the same time, the test of total bilirubin and prothrombin activity in the clinical diagnosis and treatment of hepatitis B is significant.