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从1979年至1983年,共收治113例首次复发的儿童急性淋巴细胞白血病(ALL),本文总结98例符合条件的并可评价疗效患者的治疗和随访结果。各病例诊断时年龄小于21岁,未曾受过蒽环类抗生素、硫鸟嘌呤和阿糖胞苷化疗。诱导缓解用VAP方案:长春新碱2mg/m~2/周,阿霉素30mg/m~2/日×3天,强的松60mg/m~2/日,三周一疗程,连续二疗程。维持化疗时将患者随机分为二组,一组以TA方案与MC方案交替,另一组在TA与MC交替二次后,加VAP方案一次(TA方案:硫鸟嘌呤100mg/
From 1979 to 1983, a total of 113 cases of children with acute lymphocytic leukemia (ALL) were treated for the first time. This article summarizes the treatment and follow-up results of 98 eligible patients who can evaluate efficacy. The age at diagnosis of each case was less than 21 years old and had not received chemotherapy for anthracycline antibiotics, thioguanine, and cytarabine. VAP regimen for induction of remission: vincristine 2 mg/m 2/week, doxorubicin 30 mg/m 2/day 3 days, prednisone 60 mg/m 2/day, 3 weeks course of treatment, 2 consecutive courses. During chemotherapy, patients were randomly divided into two groups. One group alternated with TA regimen and MC regimen. The other group was treated with alternating TA and MC twice and VAP regimen once (TA regimen: thioguanine 100 mg/day).