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目的:探讨血管内皮生长因子(VEGF)和碱性成纤维细胞生长因子(bFGF)急性白血病(AL)患儿血清中的表达及其与临床意义。方法:采用ELISA方法检测40例初治AL患儿化疗前及治疗1疗程后37例患儿和40例健康儿童血清中VEGF和bFGF的水平。结果:治疗前,AL组以及ALL组、ANLL组血清VEGF和bFGF水平均显著高于对照组(P<0.05),而血清VEGF和bFGF水平在AL不同类型之间差异无统计学意义(P>0.05)。治疗前,AL缓解(CR)和未缓解(NR)患儿血清VEGF和bFGF水平差异无统计学意义;治疗后,CR患儿血清VEGF和bFGF水平显著下降,与治疗前和NR患儿比较均有显著性差异(P<0.05);而NR患儿治疗前后血清VEGF和bFGF水平差异无统计学意义。结论:VEGF和bFGF在AL患儿血清中呈高表达,血清VEGF和bFGF水平可作为AL患儿疗效观察指标,并且与患儿的预后有关。
Objective: To investigate the expression and clinical significance of serum in patients with vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) acute leukemia (AL). Methods: Serum levels of VEGF and bFGF in 40 children with AL were measured by ELISA before treatment and after 1 course of treatment in 37 children and 40 healthy children. Results: Before treatment, the levels of VEGF and bFGF in AL group, ALL group and ANLL group were significantly higher than those in control group (P <0.05), while the levels of serum VEGF and bFGF had no statistical significance in different types of AL (P> 0.05). Before treatment, serum VEGF and bFGF levels were not significantly different between children with AL and non-remission (NR). After treatment, serum VEGF and bFGF levels in children with CR were significantly lower than those before treatment and before NR treatment (P <0.05). However, there was no significant difference in serum VEGF and bFGF before and after treatment in children with NR. Conclusion: VEGF and bFGF are highly expressed in the serum of children with AL, and serum levels of VEGF and bFGF can be used as indicators of the therapeutic effect in children with AL. And they are related to the prognosis of children.