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目的:探讨缺氧诱导因子-1α(HIF-1α)和环氧合酶-2(COX-2)在食管鳞癌发展过程中的表达变化。方法:选取我院食管鳞癌患者100例(实验组)和50例正常食管上皮组织(对照组)。采用回顾性分析的方法,分析我院收治的食管鳞癌患者临床资料,测定正常上皮组织和食管鳞癌组织中HIF-1α、COX-2表达及微血管密度(MVD)。结果:食管鳞癌组织中的HIF-1α、COX-2表达阳性率均明显高于正常上皮组织(χ2=127.9、82.1,P<0.05),正常上皮组织中MVD值明显低于食管鳞癌组织中(t=26.33,P<0.05),HIF-1α和COX-2、MVD均存在明显的正相关,差异均有统计学意义(r=0.491、0.487,P<0.05)。结论:食管鳞癌组织中的HIF-1α和COX-2表达增加,其肿瘤血管增加可能与HIF-1α和COX-2有关,为食管鳞癌发展过程提供可靠的理论依据。
Objective: To investigate the expression changes of hypoxia inducible factor-1α (HIF-1α) and cyclooxygenase-2 (COX-2) in the development of esophageal squamous cell carcinoma. Methods: 100 patients with esophageal squamous cell carcinoma (experimental group) and 50 normal esophageal epithelial tissues (control group) were selected. The clinical data of patients with esophageal squamous cell carcinoma treated in our hospital were analyzed retrospectively. The expression of HIF-1α, COX-2 and MVD in normal epithelium and esophageal squamous cell carcinoma were detected. Results: The positive rates of HIF-1α and COX-2 in esophageal squamous cell carcinoma tissues were significantly higher than those in normal epithelial tissues (χ2 = 127.9,82.1, P <0.05). The MVD in normal epithelium was significantly lower than that in esophageal squamous cell carcinoma (T = 26.33, P <0.05). There was a significant positive correlation between HIF-1α and COX-2 and MVD (all P <0.05). CONCLUSIONS: The expression of HIF-1α and COX-2 in esophageal squamous cell carcinoma is increased. The increase of tumor blood vessels may be related to HIF-1α and COX-2, which may provide a reliable theoretical basis for the development of esophageal squamous cell carcinoma.