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目的观察原发性高血压患者采用氨氯地平联合缬沙坦治疗的临床效果,同时观察其对患者血压及心率的影响,为安全、高效用药提供参考。方法选取医院收治的原发性高血压患者158例,随机分为对照组和观察组,每组79例。对照组给予氨氯地平片治疗,观察组给予缬沙坦治疗。观察2组患者治疗前、后血压[收缩压(SBP)、舒张压(DBP)]、肱—踝脉搏波传导速度(BaPWV)及心率变化;统计2组临床治疗效果及治疗期间所发生的不良反应。结果治疗后,较对照组而言,观察组收缩压、舒张压、BaPWV及心率控制方面效果更为显著(P<0.05);观察组治疗总有效率为89.9%,高于对照组的62.0%(P<0.05);治疗期间2组均未见明显不良反应,未影响治疗结果。结论联合氨氯地平与缬沙坦治疗原发性高血压患者疗效显著,具有较高安全性,同时还可降低脉搏波传导速度,对逆转动脉硬化具有重要意义。
Objective To observe the clinical effect of amlodipine combined with valsartan in patients with essential hypertension and to observe its effect on blood pressure and heart rate in patients with hypertension for reference for safe and effective drug use. Methods A total of 158 patients with essential hypertension were selected and randomly divided into control group and observation group, with 79 cases in each group. The control group was treated with amlodipine, while the observation group was given valsartan. Blood pressure (systolic blood pressure (SBP), diastolic blood pressure (DBP)], brachial-ankle pulse wave velocity (BaPWV) and heart rate before and after treatment were observed before and after treatment in 2 groups. The clinical efficacy and the treatment failure reaction. Results After treatment, systolic blood pressure, diastolic blood pressure, BaPWV and heart rate control were more significant in the observation group than those in the control group (P <0.05). The total effective rate in the observation group was 89.9%, higher than that in the control group (62.0% (P <0.05). No adverse reactions were observed in the two groups during treatment, which did not affect the treatment outcome. Conclusions Combination of amlodipine and valsartan in the treatment of patients with essential hypertension has significant effect, high safety, and can reduce the pulse wave velocity, which is of great significance for the reversal of atherosclerosis.