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目的观察奥曲肽(生长抑素八肽)治疗急性胃黏膜病变出血的疗效。方法应用奥曲肽联合PPI(奥咪拉唑)治疗急性胃黏膜病变出血48例,首次给予奥曲肽0.1mg静脉推注,后25μg/h维持,奥咪拉唑40mg静推每12小时1次。并与单用奥咪拉唑治疗作对照,奥咪拉唑用药方法同治疗组。上述两组病人均用药3～4d。结果48例患者中44例有效,总有效率达91.6%。结论奥曲肽对严重应激导致的胃黏膜病变出血有显著疗效。
Objective To observe the efficacy of octreotide (somatostatin octapeptide) in the treatment of acute gastric mucosal hemorrhage. Methods 48 cases of acute gastric mucosal hemorrhage were treated with octreotide combined with PPI (omeprazole). The patients were given 0.1 mg octreotide for intravenous injection for the first time, then maintained at 25 μg / h, and 40 mg intravenously administered omeprazole once every 12 hours. And with the single use of omeprazole treatment as a control, omeprazole medication method with the treatment group. The two groups of patients medication 3 ~ 4d. Results 48 of 48 patients were effective, the total effective rate was 91.6%. Conclusion Octreotide has a significant effect on the gastric mucosal lesion hemorrhage caused by severe stress.