肝脏、肾脏作为人体两大重要的代谢器官在血液动力学和免疫机制等方面存在着密切联系。肝肾综合征是肝硬化最常见的继发性肾脏损害之一,钠潴留是其主要的病理生理表现。虽然肝硬化及肝肾综合征发病机制得到了广泛研究,但目前钠潴留启动机制及维持因素尚不完全清楚。本文就肝硬化及肝肾综合征钠潴留发生机制做一综述。 Liver, kidney as the body’s two major metabolic organs in the hemodynamics and immune mechanisms there is a close link. Hepatorenal syndrome is one of the most common secondary renal lesions of liver cirrhosis, sodium retention is its main pathophysiological manifestations. Although the pathogenesis of cirrhosis and hepatorenal syndrome has been extensively studied, the mechanism of sodium retention and the maintenance factors are not yet fully understood. This article reviews the pathogenesis of cirrhosis and hepatorenal syndrome sodium retention.