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本文采用放免法和硫代巴比妥酸比色法测定了104例甲肝患者和30例健康对照组的血清SOD和LPO水平。结果甲肝急性病期SOD降低,LPO升高,恢复期患者这些指标则可恢复正常。本文结果提示,甲肝患者发病后可出现氧自由基代谢紊乱,其发生与肝细胞损伤有关。动态观察血清SOD和LPO水平的变化对临床上判断肝细胞的损害程度和评估预后上有一定的意义。
In this paper, 104 cases of hepatitis A patients and 30 healthy controls were measured serum SOD and LPO levels by radioimmunoassay and thiobarbituric acid colorimetry. Results During the acute phase of hepatitis A, the SOD decreased and the LPO increased. These indexes returned to normal in the convalescent patients. The results suggest that, after onset of hepatitis A patients may appear oxygen free radical metabolism, the occurrence of liver cell damage. Dynamic observation of serum SOD and LPO levels of changes in the clinical judgment of the degree of damage to the liver cells and evaluate the prognosis of a certain significance.