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目的探讨系膜增生性肾小球肾炎治疗前后血清IL-6、IL-10、IL-13水平的变化及意义。方法采用ELISA法对38例患者进行血清含量水平检测,并与35名正常健康者作比较。结果观察组治疗前血清IL-6、IL-10、IL-13水平较正常对照组高,差异有统计学意义(P<0.05)。治疗后患者血清水平与治疗前相比降低,差异有统计学意义(P<0.05)。结论检测系膜增生性肾小球肾炎患者血清IL-6、IL-10、IL-13水平的变化对临床观察预后有重要的临床价值。
Objective To investigate the changes and significance of serum IL-6, IL-10 and IL-13 in patients with mesangial proliferative glomerulonephritis before and after treatment. Methods Serum levels of 38 patients were detected by ELISA and compared with 35 healthy controls. Results The serum levels of IL-6, IL-10 and IL-13 in observation group before treatment were significantly higher than those in normal control group (P <0.05). Serum levels of patients after treatment decreased compared with before treatment, the difference was statistically significant (P <0.05). Conclusion The detection of serum IL-6, IL-10, IL-13 levels in patients with mesangial proliferative glomerulonephritis has important clinical value in clinical observation and prognosis.