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目的 探讨急性白血病 (AL)患者血清白细胞介素 - 2 (IL- 2 )及血液 T细胞亚群水平。方法 采用酶联免疫吸附试验 (EL ISA)及荧光免疫法测定 30例急性白血病患者白细胞介素 - 2及血液 T细胞亚群水平 ,并与对照组比较。结果 AL患者 IL - 2含量显著低于对照组 (P<0 .0 1) ,T细胞亚群中 CD3+ 、CD4 + 均低于对照组水平 (P<0 .0 1) ,CD8+ 高于对照组水平 (P>0 .0 5 ) ,经治疗缓解患者 IL- 2、CD3+、CD4 +、CD8+达正常水平。结论 IL- 2和 T细胞亚群可作为 AL 辅助诊断指标 ,为临床治疗提供实验依据。
Objective To investigate the levels of serum interleukin - 2 (IL - 2) and blood T lymphocyte subsets in patients with acute leukemia (AL). Methods The levels of interleukin - 2 and blood T lymphocyte subsets in 30 patients with acute leukemia were determined by enzyme - linked immunosorbent assay (ELISA) and fluorescence immunoassay, and compared with the control group. Results The level of IL - 2 in AL patients was significantly lower than that in control group (P <0.01). The levels of CD3 + and CD4 + in T lymphocyte subsets were lower than those in control group (P <0.01) (P> 0.05). The levels of IL-2, CD3 +, CD4 + and CD8 + in patients were relieved after treatment. Conclusion The IL-2 and T cell subsets may be used as auxiliary diagnostic indicators for AL, providing experimental evidence for clinical treatment.