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本文应用鼠伤寒沙门菌／徽粒体试验，小鼠骨髓细胞微核试验和体外哺乳动物细胞（ＣＨＬ）染色体畸变试验对钆喷酸二葡甲胺进行了致突性研究．结果表明：钆喷酸二葡甲胺各剂量ＴＡ９７，ＴＡ９８，ＴＡ１００，ＴＡ１０２在加和不加Ｓ９条件下均无致突性。在徽核试验中，各剂量诱发小鼠骨髓多染红细胞的微核率与阴性对照相比，无显著差异（Ｐ＞０．０５）染色体畸变试验也未观察到钆喷酸二葡甲胺对体外培养细胞的损伤作用．研究表明，钆喷酸二葡甲胺对原核生物和哺乳动物细胞无致突变作用．
In this paper, the Salmonella typhimurium / porcupine body test, mouse bone marrow cell micronucleus test and in vitro mammalian cells (CHL) chromosome aberration test gadodiamide gadolephate mutagenicity. The results showed that the doses of TAg97, TA98, TA100 and TA102 of gadopentetate dimeglumine did not show any intimacy with and without S9. There was no significant difference (P> 0.05) in micronucleus rate of mouse erythrocytes in bone marrow induced by different dosages in the nuclear test of nuclear test In vitro cultured cell injury. Studies have shown that gadopentetate dimeglumine does not cause mutations in prokaryotes and mammalian cells.