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为探讨低剂量钷－ １４７ （１４７ Ｐｍ） 对小鼠的内污染效应， 应用骨髓和血液嗜多染红细胞微核检测方法， 观察了低剂量１４７Ｐｍ 内污染小鼠能否改变相继高剂量１４７Ｐｍ 内污染引起的染色体损伤效应。结果显示， １８－５ ｋＢｑ／ｇ体重的单纯高剂量１４７Ｐｍ 内污染可引进骨髓和血液嗜多染红细胞微核细胞率明显增多， 与正常对照组比较有非常显著的差异（ Ｐ＜ ０－００１） 。然而，预先应用０－３７ ， ３－７ 和３７ Ｂｑ／ｇ 体重的１４７ Ｐｍ 内污染预处理动物， ３ 天后应用相同的高剂量１４７ Ｐｍ（１８－５ ｋＢｑ／ｇ 体重） 内污染机体， 骨髓和血液嗜多染红细胞微核细胞率明显减少， 与单纯高剂量１４７Ｐｍ 内污染实验组相比有非常显著的差异（ Ｐ＜ ０－０１ 或Ｐ＜ ０－００１） ； 并且０－３７ ～３－７ Ｂｑ／ｇ 体重１４７Ｐｍ 内污染预处理组的骨髓嗜多染红细胞微核细胞率和０－３７ Ｂｑ／ｇ 体重１４７Ｐｍ 内污染预处理组的血液嗜多染红细胞微核细胞率与正常对照组相比已无显著性差异（ Ｐ＞０－０５） 。结果表明， 低剂量１４７Ｐｍ 内污染预处理动物， 可诱导红细胞系统的放射适应性反应，使红细胞系统对相继高剂量１４７Ｐｍ 内污染引起的染色体损伤有了明显的
In order to investigate the effect of low dose 钷-147 (147 Pm) in mice, the bone marrow and blood polychromatic erythrocyte micronucleus test were used to observe whether the low dose 147Pm contaminated mice could alter the high dose of 147Pm Chromosome damage caused by the effect. The results showed that the simple and high-dose 147Pm contamination of 18-5 kBq / g body weight could significantly increase the rate of micronuclei in bone marrow and blood polychromatic erythrocytes, which was significantly different from the normal control group (P <0-001) . However, animals pre-contaminated with 147 Pm of 0-37, 3-7, and 37 Bq / g of body weight were pre-treated with the same high dose of 147 Pm (18-5 kBq / g body weight) The number of micronucleated cells in erythrocytes of erythrocytes was significantly decreased, which was significantly different from that of the experimental group (P <0-01 or P <0-001); and 0-37 ~ 3-7 Bk / g body weight within 147Pm pretreatment group of bone marrow polychromatic erythrocyte micronucleated cells and 0-37 Bq / g body weight 147Pm within the pollution pretreatment group of blood polychromatic erythrocyte micronucleated cells compared with the normal control group There was no significant difference (P> 0-05). The results showed that the low dose of 147Pm contaminated pretreated animals, can induce the adaptive response of the erythrocyte system of radiation, so that the red blood cell system at high doses 147Pm pollution caused by chromosome damage have obvious