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目的:探讨LEEP诊治宫颈上皮内瘤变(CIN)的临床价值。方法:对门诊收治患者中行TCT、阴道镜、宫颈组织学三阶梯检查确定为宫颈上皮内瘤病变423例进行LEEP治疗及随访分析。结果:423例CIN行LEEP病理结果 CINⅠ、Ⅱ、Ⅲ分别为123例、113例、137例,慢性炎症37例,浸润癌12例(Ⅰa18例、Ⅰa22例、Ⅰb 2例),微偏腺癌1例,术后病理CINⅢ的例数增加,宫颈癌检出率3.07%。同时发现30～39岁年龄段CIN发病率最高,30～39岁与50～59岁年龄段比较发病率差异有统计学意义(P<0.05),余组发病率差异无统计学意义。随访术后1～2个月内CIN的患者宫颈大部分恢复如初,有4例行第2次LEEP,LEEP一次成功率为99.05%,部分患者失访,随访中大部分患者效果满意,未发现CIN复发的病例。结论:LEEP是目前治疗宫颈病变的最佳方法,也是预防及发现早期宫颈癌的有效方法。
Objective: To investigate the clinical value of LEEP in diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Methods: TCT, colposcopy and cervical histology were performed in outpatients, 423 cases of cervical intraepithelial neoplasia were treated by LEEP and follow-up analysis. Results: The pathological results of LEEP in 423 cases of CIN were 123 cases, 113 cases, 137 cases, 37 cases of chronic inflammation, 12 cases of invasive carcinoma (Ⅰa18 cases, Ⅰa22 cases, Ⅰb 2 cases), micro-adenocarcinoma 1 case, postoperative pathological CIN Ⅲ cases increased, cervical cancer detection rate of 3.07%. The incidence of CIN in the age group of 30-39 years old was also found to be the highest. The incidence of CIN in the age group of 30-39 years and the age group of 50-59 years was significantly different (P <0.05). There was no significant difference in the incidence of CIN between the two groups. Follow-up Within 1 to 2 months after operation, most of the patients with CIN returned to their original condition. The second LEEP was performed in 4 cases, and the success rate of LEEP was 99.05% at one time. Some patients were lost to follow-up, most of the patients were satisfied with the results and were not found CIN recurrence of the case. Conclusion: LEEP is the best method for treating cervical lesions and is an effective method to prevent and detect early cervical cancer.