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背景 一般认为抗体重链(H)在决定抗原的特异性方面比轻链更重要。抗-D抗体H链在结合抗原的重要作用已被充分认识,但对L链功能的认识却很少。在这项研究中,通过除去L链以研究非D免疫供者抗-D抗体L链在决定抗体的特异性和反应性方面的功能。研究设计和方法 在噬菌体介导系统
Background It is generally accepted that antibody heavy chains (H) are more important than light chains in determining the specificity of an antigen. The important role of the anti-D antibody H chain in binding antigen has been well recognized, but little is known about the function of L chain. In this study, the function of determining the specificity and reactivity of antibodies by studying the L chain to study the L chain of anti-D antibody non-D immun donor. Research design and methods in phage-mediated systems