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本文综述了我国卅年来抗结核药物耐药性及其有关问题。说明影响继发耐药率的因素甚多,但不合理化疗不坚持或不规则用药仍是其主要因素。耐药菌的复治疗效较差,虽实验表明耐药菌尤以耐 H 菌的致病力有减低,但在社会人群中耐药菌的致病力尚待研究。由于各地耐药性测定方法,技术措施等不一,致各地报告的耐药率差异甚大,故也无对比价值。此外,贯彻“查出必治,治必彻底”方针及化疗五原则是防止或减少耐药菌产生的最有力手段.也是控制结核病总体规划中的重要一环。
This article reviews the anti-TB drug resistance and its related problems in China in recent years. There are many factors affecting the rate of secondary drug resistance, but irrational chemotherapy is not persistent or irregular medication is still the main factor. Resistant bacteria complex curative effect is poor, although the experimental results show that the resistance of bacteria resistant to H bacteria has reduced the virulence, but in the community population of resistant bacteria virulence yet to be studied. Due to the different drug resistance measurement methods and technical measures, the drug resistance rates reported across the country vary greatly, so there is no comparison value. In addition, the implementation of the principle of “treating all will rule and thoroughly eliminating” and the Five Principles of Chemotherapy are the most powerful means to prevent or reduce the emergence of drug-resistant bacteria and an important part of the overall plan for controlling tuberculosis.