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作为治疗冠状动脉粥样硬化后狭窄的手段,经皮内腔冠状动脉成形术(percutaneoustransluminalcoronaryangio-plasty,PTCA)的手术成功率已达到95%以上,但术后6个月内为再狭窄发生率30～50%。再狭窄发生的关键是血管损伤后平滑肌细胞(vascularsmoothmusclecell,VSMC)的增殖和迁移。
Surgical success rate of percutaneous transluminal coronary angioplasty (PTCA) has reached more than 95% as a means of treating post-coronary atherosclerosis, but the incidence of restenosis within 6 months after operation ~ 50%. The key of restenosis is the proliferation and migration of vascularsmooth muscle cells (VSMC) after vascular injury.