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本实验用24只封闭群雌性大耳白家兔,随机将动物均分为对照组、发热组和电针组3组。检测3组动物不同脑区组织前列腺素E_2(PGE_2)含量,发热组动物PGE_2含量明显升高,与对照组动物比较差异显著(P<0.05),电针组动物PGE_2含量的增加受到抑制,与发热组动物比较差异显著(P<0.05)。发热组动物脑皮质和脑干组织PGE_2含量与对照组和电针组比较无显著性差异。本实验进一步证实:PGE_2是发热的中枢性介质,ET引起体温升高时,丘脑下部组织PGE_2的含量增加,电针抑制体温的升高与丘脑下部组织PGE_2的含量增加受到抑制有关。
In this experiment, 24 female white-bearing rabbits were used to confine the animals. The animals were randomly divided into control group, fever group and EA group. The content of prostaglandin E 2 (PGE 2) in different brain regions of three groups of animals was detected. The content of PGE 2 in the animals in the fever group was significantly higher than that in the control group (P<0.05). The increase of PGE 2 content in the electroacupuncture group was inhibited. The animals in the fever group were significantly different (P<0.05). There was no significant difference in the PGE 2 content in cerebral cortex and brainstem between animals in the fever group and the control group and electroacupuncture group. This experiment further confirmed that: PGE 2 is a central medium of fever, ET caused by elevated body temperature, PGE 2 content in the hypothalamus increased, electro-acupuncture inhibition of body temperature and PAL_2 of the hypothalamus tissue increased content is inhibited.