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目的:探讨腹腔镜子宫肌瘤切除术后复发的危险因素，为临床防治提供参考。方法:回顾性分析2016年6月至2018年12月在山东省宁津县人民医院行腹腔镜子宫肌瘤切除术的216例患者的临床资料，术后随访12个月，应用单因素分析及多因素Logistic回归模型筛选影响腹腔镜子宫肌瘤切除术后复发的危险因素。结果:术后随访12个月，216例患者中24例复发，复发率为11.11%。单因素分析显示，腹腔镜子宫肌瘤切除术后复发与手术年龄、初潮年龄、肌瘤数目、子宫大小、术中是否应用超声及术后是否行促性腺激素释放激素激动剂（GnRH-a）治疗相关（n P0.05）。多因素Logistic回归分析显示，手术年龄≥ 35岁（n OR=1.289，95% n CI 1.013~1.641）、初潮年龄<13岁（n OR=1.765，95% n CI 1.167~2.669）、肌瘤数目≥ 2个（n OR=2.487，95% n CI 1.442~4.288）是腹腔镜子宫肌瘤切除术后复发的独立危险因素（n P<0.05），而术中应用超声（n OR=0.772，95% n CI 0.616~0.967）、术后行GnRH-a治疗（n OR=0.696，95% n CI 0.510~0.951）是保护因素（n P<0.05）。受试者工作特征（ROC）曲线分析显示，手术年龄≥ 35岁、初潮年龄<13岁、肌瘤数目≥ 2个预测腹腔镜子宫肌瘤切除术后复发的曲线下面积分别为0.641（95%n CI 0.573~0.705）、0.719（95% n CI 0.654~0.778）、0.622（95% n CI 0.554~0.687），以初潮年龄<13岁的诊断效能最大。n 结论:手术年龄≥ 35岁、初潮年龄<13岁、肌瘤数目≥ 2个是腹腔镜子宫肌瘤切除术后复发的独立危险因素，而术中应用超声、术后行GnRH-a治疗有助于降低术后复发风险。“,”Objective:To explore the risk factors of recurrence after laparoscopic myomectomy and provide references for clinical prevention and treatment.Methods:The clinical data of 216 patients who underwent laparoscopic myomectomy in Ningjin County People′s Hospital from June 2016 to December 2018 were analyzed retrospectively. The recurrence rate at 12 months after the operation was followed up, and the risk factors influencing the recurrence after laparoscopic myomectomy were screened by univariate analysis and multivariate Logistic regression model.Results:After followed up for 12 months after the operation, 24 cases had recurrence, with a recurrence rate of 11.11%(24/216). Univariate analysis showed that the recurrence after laparoscopic myomectomy was significantly correlated with surgical age, age at menarche, number of fibroids, uterine size, and gonadrotropin releasing hormone agonist (GnRH-a) treatment after the operation (n P0.05). Multivariate Logistic regression analysis showed that surgical age ≥ 35 years old (n OR=1.289, 95% n CI 1.013-1.641), age at menarche <13 years old ( n OR=1.765, 95% n CI 1.167 - 2.669), and number of fibroids ≥ 2 (n OR=2.487, 95% n CI 1.442 - 4.288) were independent risk factors for recurrence after laparoscopic myomectomy (n P<0.05), while GnRH-a treatment after the operation (n OR = 0.696, 95% n CI 0.510-0.951) was its protective factor (n P<0.05). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve of surgical age ≥ 35 years old, menarche age <13 years old, and number of fibroids ≥ 2 for predicting recurrence after laparoscopic myomectomy was 0.641 (95%n CI 0.573 - 0.705), 0.719 (95% n CI 0.654 - 0.778) and 0.622 (95%n CI 0.554 - 0.687), and age at menarche had the greatest diagnostic efficiency.n Conclusions:Surgical age ≥ 35 years old, age at menarche <13 years old, and number of fibroids ≥ 2 are independent risk factors for recurrence after laparoscopic myomectomy. Intraoperative ultrasound and postoperative GnRH-a treatment can help reduce the risk of postoperative recurrence.