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目的评价辛伐他汀对2型糖尿病并发症的近期疗效。方法 75例2型糖尿病患者随机分为对照组和治疗组,其中对照组42例患者接受常规方法治疗,治疗组33例患者在常规治疗的基础上加服辛伐他汀。观察两组肾功能、血糖、视力指标。结果治疗组与对照组在治疗前两组间的血糖指标、肾功能指标及视力水平比较差异无统计学意义(P>0.05)。两组患者治疗前与治疗3个月后,肾功能指标[肾小球滤过率(UAER)、尿素氮(BUN)、血肌酐(Scr)]、空腹血糖指标[葡萄糖(Glu)]均与治疗前有明显差异,治疗后较治疗前肾功能改善。两组治疗后肾功能指标(UAER、BUN、SCr)比较,差异有统计学意义(P<0.05),治疗组较对照组有明显改善。两组治疗后血糖指标比较差异无统计学意义(P>0.05)。两组治疗后视力下降率比较差异无统计学意义(P>0.05)。结论在常规治疗的基础上,加用他汀类药物对早期糖尿病患者实施治疗,可有效改善肾功能指标,对肾脏起到保护作用,效果显著。
Objective To evaluate the immediate effect of simvastatin on the complication of type 2 diabetes. Methods 75 patients with type 2 diabetes mellitus were randomly divided into control group and treatment group, in which 42 patients in control group received routine treatment, and 33 patients in treatment group received simvastatin on the basis of routine treatment. Two groups were observed renal function, blood glucose, visual acuity. Results There were no significant differences in blood glucose, renal function and visual acuity between the two groups before treatment in the treatment group and the control group (P> 0.05). Before treatment and 3 months after treatment, the renal function indexes (such as UAER, BUN and Scr) and fasting blood glucose (Glu) Significantly different before treatment, after treatment than before treatment, renal function improved. After treatment, the renal function indexes (UAER, BUN, SCr) in the two groups were significantly different (P <0.05), and the treatment group had a significant improvement over the control group. There was no significant difference in blood glucose between two groups after treatment (P> 0.05). There was no significant difference in the rate of vision loss between the two groups after treatment (P> 0.05). Conclusion On the basis of routine treatment, adding statins to patients with early-stage diabetes can effectively improve the renal function indexes and play a protective role on the kidneys, with a significant effect.