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目的 :观察低分子肝素治疗急性脑梗死的疗效及治疗前后的血液流变学变化。方法 :对 12 8例急性脑梗死患者应用低分子肝素 0 4ml ,每 12h腹部皮下注射 1次 ,连续 10天为 1疗程 ;对照组 10 0例急性脑梗死患者用低分子右旋糖酐 5 0 0ml加复方丹参16ml静滴 ,每日 1次 ,连用 10天。治疗前后检测血液流变学指标。结果 :治疗组疗效明显高于对照组 (P <0 0 1) ,且能降低全血高切粘度、低切粘度、血浆粘度、红细胞压积、纤维蛋白原等。CT检查显示治疗组病灶缩小较对照组有显著性差异 (P <0 0 1) ,脑地形图检测亦显示治疗后有明显改善。结论 :低分子肝素治疗急性脑梗死能显著改善临床症状 ,降低血液流变学指标。
Objective: To observe the therapeutic effect of low molecular weight heparin on acute cerebral infarction and the changes of hemorheology before and after treatment. Methods: 128 cases of acute cerebral infarction patients with low molecular weight heparin 0 4ml every 12h abdominal subcutaneous injection for 10 days for a course of treatment; control group of 10 patients with acute cerebral infarction with low molecular weight dextran 500ml plus compound Danshen 16ml intravenous infusion, once daily, once every 10 days. Before and after treatment to detect blood rheology indicators. Results: The treatment group was significantly higher than the control group (P <0.01), and can reduce the whole blood high shear viscosity, low shear viscosity, plasma viscosity, hematocrit, fibrinogen and so on. CT examination showed that the shrinkage of the treated group was significantly different from that of the control group (P <0.01). The brain topographic examination also showed significant improvement after treatment. Conclusion: The treatment of acute cerebral infarction with low molecular weight heparin can significantly improve the clinical symptoms and reduce the indexes of hemorheology.