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目的观察益气解毒颗粒配合放射治疗鼻咽癌的临床疗效。方法应用益气解毒颗粒配合放射治疗鼻咽癌35例,并选择纯放射治疗的35例作为对照组,进行临床疗效、急性毒副反应及细胞免疫功能对比观察和治疗后随访。结果①治疗组鼻咽部及颈部肿瘤消退率显著优于对照组(P<0.05);②治疗组鼻咽癌及颈肿瘤消退时的放射治疗剂量(简称肿瘤消退剂量)明显低于对照组(P<0.05);③治疗组急性毒副反应明显低于对照组(P<0.05);④治疗组放疗后T淋巴细胞亚群无显著变化,而对照组CD3、CD4、CD8水平放疗后显著降低,与放疗前比较差异有显著性(P<0.05);⑤治疗组3年生存率明显优于对照组(P<0.05)。结论中药益气解毒颗粒配合放射治疗鼻咽癌可以降低肿瘤消退剂量,具有放射增敏效果,减轻放疗副反应,改善机体细胞免疫功能,提高远期生存率。
Objective To observe the clinical efficacy of Yiqi Jiedu Granule combined with radiation in the treatment of nasopharyngeal carcinoma. Methods 35 cases of nasopharyngeal carcinoma were treated with Yiqijiedu Granules combined with radiotherapy and 35 cases of pure radiotherapy were selected as control group. Clinical efficacy, acute toxic and side effects and cellular immune function were observed and compared after treatment. Results ① The regression rate of nasopharyngeal and neck tumors in treatment group was significantly better than that in control group (P <0.05); ② The radiation treatment dose (referred to as tumor regression dose) of nasopharyngeal carcinoma and cervical neoplasm in treatment group was significantly lower than that in control group (P <0.05); ③ The acute toxicity of the treatment group was significantly lower than that of the control group (P <0.05); ④ The T lymphocyte subsets in the treatment group had no significant changes after radiotherapy, while the levels of CD3, CD4 and CD8 in the control group were significantly higher after radiotherapy (P <0.05). (3) The 3-year survival rate of the treatment group was significantly better than that of the control group (P <0.05). Conclusion Chinese medicine Yiqijiedu particles combined with radiation treatment of nasopharyngeal carcinoma can reduce tumor regression dose, with radiosensitization effect, reduce side effects of radiotherapy, improve cellular immune function and improve long-term survival rate.