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【目的】探讨脑源性神经生长因子(Brain derived neurotrophic factor,BDNF)及酪氨酸激酶受体 B (tyrosine kinase receptor B,TrkB)在子宫内膜癌(endometrial carcinoma,EC)中的表达及其意义。【方法】采用免疫组织化检测22例正常子宫内膜(正常组)、32例增生子宫内膜(增生组)、62例 EC 组织(EC 组)中的BDNF 及 TrkB 表达水平,并分析 EC 组织中 BDNF、TrkB 的表达与其临床病理特征的关系。【结果】增生组、EC 组 BDNF、TrkB 阳性表达率显著高于正常组,而 EC 组 BDNF、TrkB 阳性表达率显著高于增生组,差异均有统计学意义(P <0.05)。EC 组织中 BDNF、TrkB 的表达与肿瘤细胞分化程度、临床病理分期、肌层浸润深度、淋巴结转移的有无均显著相关(P <0.05),且 EC 组织中 BDNF 与 TrkB 的表达具有显著相关性(r =0.508,P <0.05)。【结论】BDNF 及 TrkB 在 EC 的发生、发展中起重要作用,且两者相互促进。“,”[Objective]To explore the expressions of brain-derived neurotrophic factor (BDNF)and tyro-sine kinase receptor B (TrkB)in endometrial carcinoma and analyze their clinical significances.[Methods]The expressions of BDNF and TrkB were detected by immunohistochemistry in normal endometrium (n = 22), hyperplasia endometrium (n =32)and endometrial carcinoma (n =62).And the relationship with their clini-copathological characteristics were analyzed.[Results]BDNF and TrkB were negatively or weakly positively expressed in normal endometrium while positively in hyperplasia endometrium and endometrial carcinoma.And statistically significant differences existed among three groups (P < 0.05 ).The expressions of BDNF and TrkB in endometrial carcinoma were significantly correlated with tumor cell differentiation,clinicopathologic staging,myometrial invasion and lymph node metastasis of endometrial carcinoma (P <0.05).[Conclusion]The interaction of BDNF with TrkB may play an important synergistic role in the occurrence and development of endometrial carcinoma.