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目的对比分析奥曲肽和垂体后叶素在救治肝硬化上消化道出血的疗效。方法选取我院2010年6月至2012年6月肝硬化上消化道出血的患者40例,按照数字表随机抽取的方法将其分成观察组与对照组,各有20例,两组皆给予常规处理,观察组在常规处理基础上给予奥曲肽治疗,对照组在常规处理基础上给予垂体后叶素治疗,观察对比两组的临床疗效。结果观察组治疗后疗效总有效率为80.0%(16/20),用药后出现腹胀1例,恶心呕吐1例,无心律失常案例出现;对照组治疗后疗效总有效率为60.0%(12/20),用药后出现腹胀1例,恶心呕吐2例,出现2例心律失常案例出现,两组患者临床疗效及不良反应率对比差异显著(P<0.01),具有统计学意义。结论奥曲肽和垂体后叶素均为救治肝硬化上消化道出血的疗效较好的手段,但奥曲肽效果更为显著,且不良反应少。
Objective To compare the curative effect of octreotide and pituitrin in the treatment of upper gastrointestinal bleeding in cirrhosis. Methods Forty patients with cirrhosis and upper gastrointestinal bleeding in our hospital from June 2010 to June 2012 were selected and randomly divided into observation group and control group according to the digital table. Each group had 20 cases, and both groups were given conventional The patients in the observation group were treated with octreotide on the basis of routine treatment. The control group was given pituitrin on the basis of routine treatment, and the clinical efficacy was observed and compared. Results The total effective rate of observation group was 80.0% (16/20) after treatment, 1 case of abdominal distension, 1 case of nausea and vomiting, no arrhythmia occurred in the observation group. The total effective rate of the control group after treatment was 60.0% (12 / 20). One case of abdominal distension and 2 cases of nausea and vomiting appeared after treatment. Two cases of arrhythmia appeared. There was significant difference between the two groups in clinical curative effect and adverse reaction rate (P <0.01), with statistical significance. Conclusion Both octreotide and vasopressin are effective methods for the treatment of upper gastrointestinal bleeding in cirrhosis. However, octreotide is more effective and has fewer adverse reactions.