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目的探讨雄激素去除治疗的老年男性前列腺癌患者骨代谢的变化。方法检测病理确诊为前列腺癌的老年男性患者40例(治疗组)治疗前及治疗1年后相关血清骨代谢标志物,包括骨钙素(OC)、总Ι型前胶原氨基端肽(tPINP)、Ι型胶原羧基端肽(β-CTx)、甲状旁腺激素(PTH)、钙(Ca)和磷(P)。结果与同期体检正常的老年男性40例(对照组)比较。结果治疗前两组相关骨代谢指标差异无统计学意义(P>0.05)。1年后,治疗组的tPINP和β-CTx较对照组明显升高(P<0.05)。结论检测血清tPINP和β-CTx可以帮助临床评估行雄激素去除治疗的老年男性前列腺癌患者骨代谢的变化。
Objective To investigate the changes of bone metabolism in male prostate cancer patients treated with androgen. Methods Serum markers of bone metabolism, including osteocalcin (OC), total type I procollagen aminoterminal peptide (tPINP), serum creatinine (Β-CTx), parathyroid hormone (PTH), calcium (Ca), and phosphorus (P) were measured. Results Compared with 40 normal elderly men (control group) in the same period of physical examination. Results There was no significant difference in the indexes of bone metabolism between the two groups before treatment (P> 0.05). One year later, tPINP and β-CTx in the treatment group were significantly higher than those in the control group (P <0.05). Conclusion The detection of serum tPINP and β-CTx can help to evaluate the changes of bone metabolism in elderly male prostate cancer patients undergoing androgen ablation.