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涎腺导管癌(salivary duct carcinoma,SDC)是一种高度恶性的、多发于老年人及大唾液腺的、预后很差的肿瘤。为证实某些生物标志物能否作为SDC侵袭性的客观测量指标,作者进行了以下实验。检查了30例SDC患者的p53,c-erbB-2,增殖性细胞核抗原(PCNA)及DNA成份的表达,及其与患者预后的关系。 材料和方法 本实验包括23名男性及7名女性,年龄22岁至87岁(平均61岁)。28例腮腺导管癌,2例颌下腺导管癌。其中26例肿瘤直径0.1～8.0cm(平均3.48cm)。周围淋巴结转移者73.3％(22例),远处转移者43.3％(13例)。患者均手术切除肿瘤,复发率26.6％(8例)。按WHO标准诊断的30例SDC患者,
Salivary duct carcinoma (SDC) is a highly malignant tumor with a poor prognosis in the elderly and the large salivary glands. To confirm whether certain biomarkers can be used as objective measures of SDC invasiveness, the authors performed the following experiments. The expression of p53, c-erbB-2, proliferating cell nuclear antigen (PCNA) and DNA in 30 patients with SDC were examined and their relationship with prognosis was examined. Materials and Methods The experiment included 23 males and 7 females aged 22 to 87 years (mean, 61 years). 28 cases of parotid duct carcinoma, 2 cases of submandibular ductal carcinoma. Twenty-six of them had a diameter of 0.1 ~ 8.0cm (average 3.48cm). Surrounding lymph nodes were 73.3% (22 cases), distant metastasis 43.3% (13 cases). Patients were surgically removed tumor, the recurrence rate was 26.6% (8 cases). According to the WHO standard diagnosis of 30 cases of SDC patients,