按照美国全国毒理学方案的要求,已进行了在饮水中加入氟化钠对 F344/N 大白鼠和 BGC3F_1小白鼠的毒性和致癌性研究。在2年的研究中,饮水氟化钠浓度为0、25、100和175ppm(相当于0、11、45和79 ppm Toxicity and carcinogenicity studies of sodium fluoride in drinking water to F344 / N and BGC3F_1 mice have been performed as required by the U.S. National Toxicology Program. In a 2-year study, drinking sodium fluoride concentrations were 0, 25, 100 and 175 ppm (equivalent to 0, 11, 45 and 79 ppm