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目的：研究肿瘤坏死因子（ＴＮＦ）在急性脑梗塞时的变化及其意义。方法：用放射免疫方法测定３２例急性脑梗塞患者的血清ＴＮＦ水平及白细胞（ＷＢＣ）计数。结果：急性脑梗塞时患者血清ＴＮＦ显著增高〔（２３．６７±３．３２）ｐｍｏｌ／Ｌ〕，与正常对照组〔（８．１６±３．５６）ｐｍｏｌ／Ｌ〕比较有显著性差异（Ｐ＜０．０１）；ＴＮＦ在梗塞发生后第１、５、１０及１４日呈持续性增高，其中以第５日为最高（３０．７４±６．３３）ｐｍｏｌ／Ｌ；第１日时ＴＮＦ与ＷＢＣ呈一致性改变。结论：急性脑梗塞后的ＴＮＦ持续性增高与脑梗塞后的ＴＮＦ双重合成有关，ＴＮＦ引发的血管内皮细胞白细胞血小板环路激活过程是脑缺血性损害的基本病理过程。
Objective: To study the changes of tumor necrosis factor (TNF) in acute cerebral infarction and its significance. Methods: Serum TNF levels and leukocyte counts (WBC) were measured in 32 patients with acute cerebral infarction by radioimmunoassay. Results: Serum TNF was significantly increased in patients with acute cerebral infarction 〔(23.67 ± 3.32) pmol / L〕, which was significantly different from that of the control group [(8.16 ± 3.56) pmol / L〕 P <0.01). TNF was consistently increased on the 1st, 5th, 10th and 14th days after infarction, with the highest on the 5th day (30.74 ± 6.33 pmol / L) TNF and WBC were consistent changes. CONCLUSION: The persistent increase of TNF after acute cerebral infarction is related to the double synthesis of TNF after cerebral infarction. The activation of leukocyte-induced platelet by vascular endothelial cells induced by TNF is the basic pathological process of cerebral ischemic damage.