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目的探讨手术切除联合角膜缘干细胞移植及氟尿嘧啶治疗翼状胬肉临床疗效。方法选择2006年10月至2009年3月收治的角膜缘翼状胬肉患者120例(均为单眼),随机分为3组,各40例,A组给予手术切除联合角膜缘干细胞移植及氟尿嘧啶治疗,B组给予手术切除胬肉+羊膜移植治疗,C组患者单纯给予翼状胬肉手术切除;观察3组治疗效果。结果 3组术后随访1～2年,平均(16.5±1.5)个月;A组患者术后不适症状轻时间短,角膜创面愈合快,术后治愈37例,复发3例,B组治愈32例,复发8例,C组治愈26例,复发14例,其中A组患者术后复发率明显低于其他两组(P<0.05)。结论手术切除联合角膜缘干细胞移植及氟尿嘧啶治疗翼状胬肉,术后复发率低,并发症少,愈合时间短,值得应用。
Objective To investigate the clinical efficacy of surgical resection combined with limbal stem cell transplantation and fluorouracil in the treatment of pterygium. Methods 120 patients with corneal limbal pterygium (both monocular) admitted to our hospital from October 2006 to March 2009 were randomly divided into 3 groups (n = 40). Group A received surgical resection combined with limbal stem cell transplantation and fluorouracil treatment , Group B was treated with surgical excision of pterygium + amniotic membrane transplantation, group C patients were given surgical resection of pterygium only; the effect of three groups were observed. Results The three groups were followed up for 1 to 2 years, with an average of (16.5 ± 1.5) months. In group A, the symptoms of postoperative discomfort were light and short, corneal wound healing was rapid, 37 cases were cured, 3 cases were relapsed, and 32 cases were cured in group B Cases, recurrence in 8 cases, C group cured 26 cases, recurrence in 14 cases, including group A patients postoperative recurrence rate was significantly lower than the other two groups (P <0.05). Conclusions Surgical resection combined with limbal stem cell transplantation and fluorouracil for the treatment of pterygium has the advantages of low postoperative recurrence rate, less complications and shorter healing time, which deserves application.