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目的:探讨bcl-2蛋白在原发性肺鳞癌中的表达及其意义。方法:应用s—p免疫组化方法检测手术切除后随访5年以上的66例肺鳞癌标本中bcl—2蛋白的表达。结果:bcl—2蛋白在原发性肺鳞癌中表达阳性率为27.3％(18/66),其表达与分化程度密切相关(X~2=10.09,P<0.005;x~2=7.58,P<0.01)。淋巴结癌转移阳性组bcl—2蛋白阳性表达率(28.6％),淋巴结癌转移阴性组(26.6％)。bcl—2蛋白表达阳性组病人的预后显著差于bcl—2蛋白阴性表达组(X~2=9.37,P<0.005):结论:bcl—2蛋白表达的改变对肺鳞癌的生物学行为起一定作用,并可作为评估预后的指标。
Objective: To investigate the expression and significance of bcl-2 protein in primary lung squamous cell carcinoma. METHODS: The expression of bcl-2 protein in 66 specimens of lung squamous carcinoma after 5 years of follow-up was detected by s-p immunohistochemistry. Results: The positive expression rate of bcl-2 protein in primary lung squamous cell carcinoma was 27.3% (18/66), and its expression was closely related to the degree of differentiation (X~2=10.09, P<0.005; x~2=7.58, P<0.01). The positive expression rate of bcl-2 protein in lymph node metastasis positive group (28.6%) and lymph node metastasis negative group (26.6%). The prognosis of patients with positive expression of bcl-2 protein was significantly lower than that of patients with negative expression of bcl-2 protein (X~2=9.37, P<0.005): Conclusions: The change of bcl-2 protein expression may play a role in the biological behavior of lung squamous cell carcinoma. A certain role, and can be used as an indicator of prognosis.