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目的探讨颈动脉粥样硬化斑块形成过程中的常见危险因素,为早期防治心脑血管疾病提供临床依据。方法收集2009年8月至2013年8月在邯郸矿业集团总医院内科住院的患者160例,均进行颈动脉彩超检测,根据颈动脉彩超检测结果是否有颈动脉斑块分为斑块组(98例)和非斑块组(62例),抽取空腹静脉血检测上述患者的三酰甘油、总胆固醇、高密度脂蛋白、低密度脂蛋白、空腹血糖,记录患者是否有高血压、糖尿病史,并进行统计学分析。结果两组间单因素比较显示斑块组年龄、性别、吸烟史、血脂水平、尿酸水平、纤维蛋白原浓度、糖尿病史、高血压病史明显高于非斑块组。结论颈动脉斑块形成是多因素作用的结果,三酰甘油、总胆固醇、低密度脂蛋白是颈动脉斑块形成的危险因素,糖代谢异常、高血压病史、高纤维蛋白原浓度、高尿酸、有吸烟、饮酒史者斑块生长率明显增加更易形成颈动脉斑块,也是颈动脉斑块形成的相关危险因素。
Objective To explore common risk factors in the formation of carotid atherosclerosis plaque and provide a clinical basis for the prevention and treatment of cardiovascular and cerebrovascular diseases in the early stage. Methods Totally 160 patients hospitalized in Handan Mining General Hospital from August 2009 to August 2013 were examined by carotid ultrasonography. According to the results of carotid ultrasonography, whether carotid plaques were divided into plaque group (Non-plaque group) and non-plaque group (62 cases). Fasting venous blood was collected to detect triglyceride, total cholesterol, high density lipoprotein, low density lipoprotein and fasting plasma glucose in the patients. The patients’ history of hypertension, diabetes mellitus, And statistical analysis. Results One-way comparison between the two groups showed that age, gender, smoking history, blood lipid level, uric acid level, fibrinogen concentration, diabetes mellitus and history of hypertension were significantly higher in plaque group than in non-plaque group. Conclusion Carotid plaque formation is the result of multiple factors. Triglyceride, total cholesterol and low density lipoprotein are the risk factors of carotid artery plaque formation. The abnormal glucose metabolism, the history of hypertension, the high fibrinogen concentration, , There is smoking, drinking history of plaque growth rate increased significantly more likely to form carotid plaque, carotid plaque is also associated with risk factors.