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目的:评价中医药联合外治法对晚期非小细胞肺癌(Non-small Cell lung Cancer,NSCLC)中医症状及免疫功能的影响。方法:以60例Ⅲb-Ⅳ期NSCLC患者为研究人群,观察路径组与非路径组患者在中医症状量化评分表及外周血T淋巴细胞水平方面的差异。结果:2组治疗后的中医症状评分均低于治疗前,临床路径组显著低于非路径组(P<0.05);2组治疗后CD8+CD28+均有所提高,路径组治疗后显著高于治疗前(P<0.05),同时显著高于非路径组(P<0.05)。结论:中医药治疗联合外治法,能有效改善晚期非小细胞肺癌患者临床症状,并可通过改变免疫状态来提高抗肿瘤能力。
Objective: To evaluate the effect of traditional Chinese medicine combined with external medicine on symptoms and immune function in patients with advanced non-small cell lung cancer (NSCLC). Methods: Totally 60 patients with stage Ⅲb-Ⅳ NSCLC were enrolled in this study. The difference between the TCM symptom score scale and the peripheral blood T lymphocyte level was observed in the pathological and non-pathological groups. Results: The score of TCM symptom in both groups after treatment was lower than before treatment, and the clinical pathology group was significantly lower than the non-pathological group (P <0.05). The CD8 + CD28 + Before treatment (P <0.05), and significantly higher than the non-pathological group (P <0.05). Conclusion: Chinese medicine treatment combined with external treatment can effectively improve the clinical symptoms of patients with advanced non-small cell lung cancer, and can improve the anti-tumor ability by changing the immune status.