Purpose: to compare the efficacy of subconjunctival administration of 5-fluorouracil (5FU) with medical therapy in controlling elevated intraocular pressure (IOP) following unsuccessful, low-risk trabeculectomy. Methods: the study included 50 consecutive patients (50 eyes) who underwent trabeculectomy without intraoperative antimetabolites, and who were not compensat- Purposes: to compare the efficacy of subconjunctival administration of 5-fluorouracil (5FU) with medical therapy in controlling elevated intraocular pressure (IOP) following unsuccessful, low-risk trabeculectomy. Methods: the study included 50 consecutive patients (50 eyes) who underwent trabeculectomy without intraoperative antimetabolites, and who were not compensat-