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目的研究老年尘肺病患者血清胱抑素C(Cys-C)浓度变化,来探讨其在老年尘肺病患者早期肾功能损伤中的价值。方法选取康复治疗的老年尘肺病患者共60例为干预组,按临床分期I期为干预组A,II期为干预组B。选取同期正常体检受试者为对照组。检测三组人员血清Cys-C、尿素氮(BUN)、血肌酐(Scr)、内生肌酐清除值(Ccr)、血糖和血脂(TC、TG),以Ccr作为肾功能损伤的诊断指标,观察血清Cys-C诊断准确性,并比较Cys-C、BUN、Scr与Ccr的相关性。结果血清Cys-C、血糖和Ccr在干预组A和B间比较差异无统计学意义,两组与对照组比较差异有统计学意义(P<0.05);BUN和Scr指标三组间两两比较差异具有统计学意义(P<0.05);血脂结果三组间两两比较差异无统计学意义(P>0.05)。Cys-C、BUN、Scr与Ccr呈现负相关性,血清Cys-C与Ccr相关性较强。结论血清Cys-C水平对反应老年尘肺病患者合并肾功能损害有较强的灵敏性,针对老年尘肺病患者检测血清Cys-C水平对预防肾功能早期损伤的发生有积极作用。
Objective To study the changes of serum cystatin C (Cys-C) levels in elderly patients with pneumoconiosis to investigate its value in the early stage of renal impairment in elderly patients with pneumoconiosis. Methods A total of 60 elderly patients with pneumoconiosis were selected as the intervention group. According to the clinical stage I, intervention group A and II were treated as intervention group B. Select the same period of normal physical examination subjects as control group. Serum levels of Cys-C, BUN, Scr, Ccr, blood glucose and blood lipid (TC, TG) were measured in three groups. Ccr was used as a diagnostic indicator of renal dysfunction. Serum Cys-C diagnostic accuracy, and compared Cys-C, BUN, Scr and Ccr correlation. Results Serum Cys-C, blood glucose and Ccr in the intervention group A and B was no significant difference between the two groups and the control group, the difference was statistically significant (P <0.05); BUN and Scr index between the two groups compared The difference was statistically significant (P <0.05); blood fat results between the two groups was no significant difference between the two groups (P> 0.05). Cys-C, BUN, Scr and Ccr showed a negative correlation, serum Cys-C and Ccr strong correlation. Conclusions Serum Cys-C level is sensitive to senile pneumoconiosis with renal dysfunction. Detecting serum Cys-C level in elderly patients with pneumoconiosis has a positive effect on the prevention of early renal injury.