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目的：研究不同基因型丙型肝炎病毒（HCV）感染后丙型肝炎（HC）患者的临床特征。方法：对90例血清HCVRNA阳性HC患者进行基因分型，并对不同型患者的临床资料进行比较。结果：（1）徐州地区HCV流行株基因型主要为Ⅱ型（78.9％），同时存在Ⅲ型（18．9％）及Ⅱ／Ⅲ混合型（2.2％）。本地区HCV基因型分布符合我国HCV基因型分布的总特征，可能反映我国东部沿海地区HCV基因型分布。（2）Ⅱ型患者肝报重于Ⅲ型，而其免疫原性低于Ⅲ型，两者在致病机理方面可能存在一定差异。（3）Ⅱ／Ⅲ混合型感染与反复输血制品及多次血液透析有关，在致病过程中可能起协同作用。
Objective: To investigate the clinical characteristics of hepatitis C (HC) patients with different genotypes of hepatitis C virus infection. Methods: Ninety patients with HCV RNA-positive HC were genotyped and the clinical data of different types of patients were compared. Results: (1) Genotypes of HCV strains in Xuzhou were mainly type Ⅱ (78.9%), type Ⅲ (18.9%) and type Ⅱ / Ⅲ mixed (2.2%). The distribution of HCV genotypes in our region is in line with the general characteristics of HCV genotype distribution in our country, which may reflect the distribution of HCV genotype in the eastern coastal areas of China. (2) Patients with type Ⅱ liver heavier than type Ⅲ, while its immunogenicity is lower than type Ⅲ, the two may have some differences in the pathogenesis. (3) Ⅱ / Ⅲ mixed infection and repeated blood transfusion products and multiple hemodialysis, may play a synergistic role in the pathogenesis.