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背景已有研究表明奥美拉唑可以预防阿司匹林引起的胃黏膜病变,但奥美拉唑是否影响阿司匹林的抗血小板凝集作用,则未见报道。目的通过血小板聚集率的检测探讨奥美拉唑对阿司匹林抗血小板作用的影响。方法入选的90例稳定型心绞痛患者被随机分为两组:对照组单用阿司匹林45例,服用阿司匹林肠溶片100 mg,1次/d;联合组45例,服用同种剂量阿司匹林肠溶片加奥美拉唑肠溶片20 mg,1次/d。两组均在给药前1天、服药后10 d分别测定血小板聚集率。比较两组患者血小板聚集率的差异。结果在两组患者中,年龄、性别、身高、体质量以及心血管疾病的危险因素(高血压、糖尿病、高血脂症等)差异无统计学意义。对照组及联合组治疗后较治疗前以花生四烯酸(ACA)和腺苷二磷酸(ADP)诱导的血小板聚集率均显著降低(P<0.05)。以ACA作诱导剂,联合组治疗后的血小板聚集率为(45.6±3.7)%,对照组为(40.2±3.6)%,差异无统计学意义(P>0.05);以ADP作诱导剂,联合组治疗后的血小板聚集率为(75.0±3.1)%,对照组为(71.6±2.8)%,差异无统计学意义(P>0.05)。结论奥美拉唑对阿司匹林的抗血小板作用无明显影响。
Background It has been reported that omeprazole can prevent aspirin-induced gastric mucosal lesions, but whether omeprazole affects aspirin’s anti-platelet aggregation has not been reported. Objective To investigate the effect of omeprazole on the antiplatelet effect of aspirin by detecting the platelet aggregation rate. Methods Ninety patients with stable angina pectoris were randomly divided into two groups: control group, aspirin alone 45 cases, taking aspirin enteric-coated tablets 100 mg once a day, combination group 45 cases, taking the same dose of aspirin enteric-coated tablets Plus omeprazole enteric-coated tablets 20 mg, 1 time / d. One day before administration and two days after administration, platelet aggregation rate was measured at 10 days after administration. Differences in platelet aggregation between the two groups were compared. Results There were no significant differences in age, sex, height, body weight and cardiovascular risk factors (hypertension, diabetes, hyperlipidemia, etc.) between the two groups. The platelet aggregation rate of arachidonic acid (ACA) and adenosine diphosphate (ADP) in control group and combination group after treatment were significantly lower than those before treatment (P <0.05). With ACA as an inducer, the platelet aggregation rate was (45.6 ± 3.7)% in the combined group and (40.2 ± 3.6)% in the control group, with no significant difference (P> 0.05). Using ADP as an inducer, The platelet aggregation rate was (75.0 ± 3.1)% in the control group and (71.6 ± 2.8)% in the control group, with no significant difference (P> 0.05). Conclusion Omeprazole had no significant effect on the antiplatelet effect of aspirin.