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检测34例糖尿病患者血浆组织型纤溶酶原激活剂(tPA)及其抑制物(PAr).α_2纤溶酶抑制物(α_2PT)及血清纤维蛋白(原)降解产物(FDP)水平,其中9例进行治疗前后动态观察。糖尿病患者血浆 tPA 活性降低含量增高,此变化与微血管病变无明显关系。血浆 PAI 与α_2PI 活性高于正常人,伴与不伴微血管病变昔比较,前者均较后者为高。血清 FDP 含量未见异常。tPA 与 PAI、α_2PI 呈负相关,PAl与α_2PI 呈正相关。治疗后 tPA 含量、PAI 活性及α_2PI 活性均降低,tPA 活性无明显变化。
The levels of tPA and PAr, α_2PT and FDP in 34 patients with diabetes mellitus were detected, of which 9 Cases of dynamic observation before and after treatment. Diabetic patients with plasma tPA activity decreased content, this change and microvascular lesions no significant relationship. Plasma PAI and α_2PI activity than normal, with and without microvascular disease compared with the former, the former is higher than the latter. No abnormal serum FDP content. There was a negative correlation between tPA and PAI and α_2PI while PAl and α_2PI were positively correlated. After treatment, tPA content, PAI activity and α 2 PI activity decreased, tPA activity did not change significantly.