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目的研究早期新生儿母亲乳汁中唾液酸水平,为母乳喂养儿尤其早产儿尽早开奶提供科学依据。方法收集122例早期新生儿母亲产后第1、4、6天母乳共284份,用神经氨酸苷酶法检测母乳唾液酸水平,统计分析采用SPSS软件17.0版,组间比较采用独立样本的t检验,相关性采用Pearson相关分析法。结果早期新生儿母亲产后第1天、第4天和第6天母乳中唾液酸含量分别为(208.6±71.6)mg/dL、(140.4±36.6)mg/dL和(139.3±37.8)mg/dL,第1天唾液酸含量显著高于第4天(t=8.100,P<0.001)和第6天(t=8.089,P<0.001)的母乳,但第4天与第6天母乳中唾液酸水平差异无统计学意义(t=0.197,P=0.844)。母乳唾液酸水平与日龄负相关(r=-0.433,P<0.001),与胎龄(r=0.049,P=0.450)和出生体重(r=0.059,P=0.340)无明显相关。结论早期新生儿母亲第1天乳汁中唾液酸含量最高,母乳唾液酸水平与日龄负相关。
Objective To study the level of sialic acid in the milk of early newborn mothers and to provide a scientific basis for early breastfeeding, especially in premature infants. Methods A total of 284 breast-feeding mothers were collected on the 1st, 4th, 6th day after delivery in 122 early mothers. The level of sialic acid in the breast milk samples was detected by neuraminidase method. Statistical analysis was performed using SPSS version 17.0. The independent samples t Test, correlation using Pearson correlation analysis. Results The levels of sialic acid in breast milk were (208.6 ± 71.6) mg / dL, (140.4 ± 36.6) mg / dL and (139.3 ± 37.8) mg / dL, respectively, on the 1st, 4th and 6th postnatal mothers , The sialic acid content of the 1st day was significantly higher than that of the 4th day (t = 8.100, P <0.001) and the 6th day (t = 8.089, P <0.001) The difference was not statistically significant (t = 0.197, P = 0.844). Breast milk sialic acid level was negatively correlated with age (r = -0.433, P <0.001), but not with gestational age (r = 0.049, P = 0.450) and birth weight (r = 0.059, P = 0.340). Conclusion The sialic acid content of breast milk in the first day of newborn mothers is the highest, and the sialic acid level of breast milk is negatively correlated with the age.