A derivative of thiazole(AAT) has been explored as a sensing material for preparation a selective Lu(III) PVC-based membrane sensor.The proposed sensor exhibits a Nernstian response over a wide concentration range from 1.0×10~(-6) to 1.0×10~(-1) mol/L of Lu(Ⅲ) and the detection limit is 5.7×10~(-7) mol/L.The sensor response is independent of pH of the solution in the range 3.2-8.8 and possesses the advantages of fast response time(～6) and in particular,good selectivity to the lutetium ions with regard to most common metal ions,and especially all lanthanide ions. A derivative of thiazole (AAT) has been explored as a sensing material for preparation of a selective Lu (III) PVC-based membrane sensor. The proposed sensor exhibits a Nernstian response over a wide concentration range from 1.0 × 10 -6 1.0 × 10 -1 mol / L of Lu (Ⅲ) and the detection limit is 5.7 × 10 -7 mol / L. The sensor response is independent of pH of the solution in the range 3.2-8.8 and possesses the advantages of fast response time (~ 6) and in particular, good selectivity to the lutetium ions with regard to most common metal ions, and especially all lanthanide ions.