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目的:探讨胎盘亮氨酸氨基肽酶(P-LAP)和白介素-6(IL-6)在正常孕妇和早产孕妇孕晚期(孕28～36+6周)母血浆中的变化趋势。方法:用酶联免疫吸附试验(ELISA法)检测孕晚期孕妇血浆中P-LAP和IL-6含量的变化。结果:(1)P-LAP的浓度随着孕周的增长而不断增加(P<0.01),IL-6的浓度不随着孕周的增长而增加(P>0.05);(2)早产组分别低于先兆早产组和足月组(P<0.01);(3)当早产组P-LAP浓度位于或低于足月组10th百分位水平时,早产发生率比先兆早产组升高(P=0.008),增加了2.15倍的危险度;(4)对研究组血浆P-LAP和IL-6浓度的相关性采用线性回归分析,无明显的相关性(P>0.05)。结论:P-LAP的浓度随着孕周的增长而不断增加,早产孕妇在入院时的血浆P-LAP低水平可以预测其预后。P-LAP水平下降,是早产和正常分娩发动的关键因素之一。
Objective: To investigate the changes of placental leucine aminopeptidase (P-LAP) and interleukin-6 (IL-6) in maternal plasma of normal pregnant women and premature pregnant women in the third trimester of pregnancy (28-36 + 6 weeks pregnant). Methods: The levels of P-LAP and IL-6 in plasma of pregnant women in the third trimester of pregnancy were detected by enzyme linked immunosorbent assay (ELISA). Results: (1) The concentration of P-LAP increased with the growth of gestational age (P <0.01), while the concentration of IL-6 did not increase with gestational age (P> 0.05) (P <0.01). (3) When the P-LAP concentration in premature labor group was at or below the tenth percentile of the full-term group, the incidence of preterm birth was higher than that in the preterm preterm group (P <0.01) = 0.008), an increase of 2.15 times the risk; (4) The study group plasma P-LAP and IL-6 concentrations using linear regression analysis, no significant correlation (P> 0.05). CONCLUSIONS: The concentration of P-LAP is increasing with gestational age, and the low plasma P-LAP levels at admission may predict the prognosis of preterm pregnant women. P-LAP levels decline, is one of the key factors in the premature delivery and normal childbirth.