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近年来的研究发现,金属硫蛋白2A(MT2A)是一种重要的抗氧化应激分子.MT2A基因多态性与冠心病、动脉粥样硬化密切相关,它具有降低脑缺血再灌注损伤和保护心肌等作用,对心脑血管疾病的影响与其对炎症、氧化应激、细胞凋亡以及内皮功能等密切相关.文章主要综述MT2A与心脑血管疾病的关系及其影响机制.“,”Recently,some studies have found that metallothionein 2A (MT2A) is an important antioxidant stress molecule.MT2A gene polymorphism is closely related to coronary heart disease and atherosclerosis.MT2A has the effect of reducing cerebral ischemia-reperfusion injury and protecting the myocardium.The effect of MT2A on cardiovascular and cerebrovascular diseases includes inflammation,oxidative stress,apoptosis and endothelial function.This article reviews the relationship between MT2A and cardiovascular,cerebrovascular diseases.