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肝硬化食管胃底静脉曲张破裂出血,是肝硬化门脉高压症最严重的并发症之一,死亡率高达30％～50％,临床上多采用综合治疗、药物、球囊压迫、内镜下硬化注射和外科手术,药物治疗方面,目前以血管加压素最为普遍,则多采用垂体后叶素,但它对心血管的副作用较大,在使用中受剂量限制,并疗效欠佳,天然生长抑素(somutostutin)为药物治疗开辟了新的前景,但因价格昂贵,半衰期短(1～2分),善得定(sondostutin)是一种人工合成的八肽,具有天然生长抑素的类似作用,并有半衰期长的优点(1～2小时),因价格昂贵,我们从1993年12月～1994年8月用善得定治疗5例食管胃底静脉曲张破裂出血,10例用垂体后叶素+凝血酶+三腔双囊管压迫治疗,并作了系统对照。
Cirrhosis esophageal varices bleeding is one of the most serious complications of cirrhosis and portal hypertension, the mortality rate as high as 30% to 50%, the clinical use of more comprehensive treatment, drugs, balloon compression, endoscopic Sclerosis injection and surgery, medical treatment, the most common vasopressin, then the use of pituitrin, but it has a greater side effects on the cardiovascular in the use of dose-limiting and curative effect of poor, natural Somutostutin has opened up new prospects for drug treatment, but due to its high cost and short half-life (1 to 2), sondostutin is a synthetic octapeptide with natural somatostatin A similar effect, and the advantages of long half-life (1 to 2 hours), due to expensive, we from December 1993 to August 1994 with good positive treatment of 5 cases of esophageal varices bleeding, 10 cases with pituitary Vasopressin + thrombin + three-chamber double cystic compression therapy, and made a systematic comparison.