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为确定白喉、破伤风及百日咳(DTP)免疫接种副作用的性质和发病率,在1978-1979年对15,725名DTP免疫接种后48小时内出现各种局部和全身反应的儿童进行预后研究。因为最初研究时,婴儿多不足1岁,神经系统损害难以测定。9名小儿出现惊厥,9名出现低张力-低反应发作发生在4次免疫后24小时内,年龄为2月～5岁,7名伴发热。低张力-低反应发作是指初次免疫指种后10小时内,患儿出现苍白、低张力、对父母无反应的异常情况,持续10分～36小时,婴儿年龄为2～18个月,7名伴发热,3名体温超过40℃。在1985年进行全面的神经系统研究包括由儿科神经病专家采集的病史和儿科临床心理学家做的精神测
To determine the nature and incidence of side effects of diphtheria, tetanus and pertussis (DTP) immunization, a prognostic study was conducted between 1978 and 1979 on 15,725 children with various local and systemic reactions within 48 hours after immunization with DTP. Because the initial study, infants less than 1 year old, the nervous system damage is difficult to determine. Nine infants had convulsions and nine had low tension - a low-response seizure occurred within 24 hours of 4 immunizations, with an age of 2 months to 5 years and 7 with fever. Low-tension - low-response seizure refers to the initial immune finger within 10 hours after the children appear pale, low tension, non-response to abnormal parents, for 10 minutes to 36 hours, infants aged 2 to 18 months, 7 Name with fever, three body temperature over 40 ℃. A comprehensive neurological study conducted in 1985 consisted of a history of pediatric neurologist acquisition and psychometric testing by pediatric clinical psychologists