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目的观察鞘内注射异烟肼和地塞米松在结核性脑膜炎治疗中的效果,探讨结核性脑膜炎有效的治疗方法。方法选取贵州省铜仁市石阡县人民医院收治的结核性脑膜炎患者65例,采用随机分组方式分为对照组和试验组,对照组32例,试验组33例。对照组接受常规的药物治疗,试验组在常规治疗的同时,接受异烟肼和地塞米松药物联合注射,统计分析两组的临床疗效及术后症状表现。结果对照组和试验组患者的治疗有效率分别为71.88%和90.91%,对照组明显低于试验组,差异有统计学意义(P<0.05);对照组和试验组患者的残障率分别为25.00%和3.03%,对照组明显高于试验组,差异有统计学意义(P<0.05)。结论常规用药基础上加用鞘内注射异烟肼和地塞米松治疗结核性脑膜炎效果显著,具有临床推广价值。
Objective To observe the effect of intrathecal administration of isoniazid and dexamethasone in the treatment of tuberculous meningitis and to explore the effective treatment of tuberculous meningitis. Methods Sixty-five patients with tuberculous meningitis who were treated in Shiqian County People’s Hospital of Tongren City, Guizhou Province were randomly divided into control group and experimental group, with 32 cases in control group and 33 cases in experimental group. The control group received conventional drug treatment. The experimental group received routine injections of isoniazid and dexamethasone, and the clinical efficacy and postoperative symptoms were statistically analyzed. Results The effective rates of the control group and the experimental group were 71.88% and 90.91%, respectively, which were significantly lower in the control group than those in the experimental group (P <0.05). The rates of disability in the control group and the experimental group were 25.00 % And 3.03% in the control group were significantly higher than the experimental group, the difference was statistically significant (P <0.05). Conclusion Conventional medication based on the addition of intrathecal isoniazid and dexamethasone treatment of tuberculous meningitis has a significant effect, with clinical value.