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目的:探讨盐酸纳美芬的药理作用及临床应用。方法:选取2014年2月~2015年2月我院收治的180例患者为研究对象,根据患者治疗需求,划分为对照组与研究组,各90例,对照组行常规治疗,研究组在对照组的基础上给予盐酸纳美芬治疗,比较两组患者的治疗情况。结果:研究组急性创伤性颅脑损伤患者的血清β-EP、NSE含量低于对照组,重症手足口病患儿的呼吸机应用率与休克发生率低于对照组,腹腔镜下异位妊娠手术患者用药10min后的苏醒率高于对照组,差异有统计学意义(P<0.05)。研究组和对照组均未出现严重不良反应。结论:盐酸纳美芬改善了患者的生存质量,临床用药安全可靠,疗效确切。
Objective: To investigate the pharmacological effects and clinical application of nalmefene hydrochloride. Methods: 180 patients admitted to our hospital from February 2014 to February 2015 were selected as the research objects. According to the patients’ needs for treatment, the patients were divided into control group and study group, with 90 cases in each group. The control group was treated routinely. Group based on nalmefene hydrochloride treatment, compared the treatment of two groups of patients. Results: Serum levels of β-EP and NSE were lower in the study group than those in the control group. The rate of ventilator application and the incidence of shock in children with severe hand-foot-mouth disease were lower than those in the control group. Laparoscopic ectopic pregnancy The recovery rate of the patients after operation for 10 minutes was higher than that of the control group (P <0.05). There was no serious adverse reaction in study group and control group. Conclusion: Nalmefene hydrochloride improves the quality of life of patients, and the clinical medication is safe and reliable with definite curative effect.