【摘 要】
：
目的 对新型含能材料二硝酰胺铵(ADN)的致突变性和致畸性进行研究,为进一步研究ADN对人体健康影响和制订职业接触限值提供依据.方法 根据《化学品毒性鉴定技术规范》,采用鼠
论文部分内容阅读
目的 对新型含能材料二硝酰胺铵(ADN)的致突变性和致畸性进行研究,为进一步研究ADN对人体健康影响和制订职业接触限值提供依据.方法 根据《化学品毒性鉴定技术规范》,采用鼠伤寒沙门杆菌回复突变试验(Ames试验)、体内哺乳动物骨髓嗜多染红细胞微核试验、精子畸形试验和致畸试验研究ADN的致突变性和致畸性.结果 (1)ADN在8～5000 μg/皿剂量范围内未发现诱变作用；113.8mg/kg剂量染毒组与阴性对照相比,诱发小鼠的微核率明显升高,差异有统计学意义(P＜0.05)；54.4～272.0 mg/kg剂量范围内小鼠精子畸形试验结果为阴性.(2)319 mg/kg剂量组活胎率低于阴性对照组,吸收胎率高于阴性对照组；319 mg/kg剂量组胎鼠胸骨1发育不全率高于阴性对照,21.3、79.7、319 mg/kg 3个剂量组胎鼠胸骨4～6发育不全率高于阴性对照组；319 mg/kg剂量组胎鼠内脏畸形率高于阴性对照组.ADN对大鼠的致畸指数为30.结论 ADN属可疑诱变剂,有致畸危害.
其他文献
Pms1, a locus for photoperiod sensitive genic male sterility in rice, was identified and mapped to chromosome 7 in previous studies. Here we report an effort to
Goat ovaries were collected from the slaughterhouse and categorized as right, left, corpus luteum (CL)-present and -absent group and evaluated on the basis of w
基于卡托普利对牛血红蛋白模拟酶催化体系的抑制作用,建立了酶催化光度法测定卡托普利的新方法。研究了该抑制反应的最佳实验条件及动力学行为,测定的线性范围为6.23×10-8～1.
Rice blast, caused by the fungal pathogen Magnaporthe oryzae, is one of the most devastating crop diseases worldwide. The avirulence gene corresponding to rice
Nanoscale NiAl-NO3-LDHs with good crystallinity have been synthesized by a method, Separate Nucleation and Aging Steps (SNAS). An NiAl-NO3-LDHs/LDPE composite w
High MW chitosan (CS) solutions have already been proposed as vehicles for protein delivery. The aim of the present work is to investigate the potential utility
Granier热消散探针法是目前研究树木生理生态和森林水文最常用的测定整树水分利用的方法之一.然而,已有的相关综述文献中,还没有专门介绍利用Granier热消散探针研究木质部液
Inducible heat shock protein 70 kD (HSP-70i) has been shown to protect cells, tissues, and organs from harmful assaults in in vivo and in vitro experimental mod
The splicing of many alternative exons in the precursor messenger RNA (pre-mRNA) is regulated by extracellular factors but the underlying molecular bases remain
Actin can be found in all kinds ofeukaryotic cells, maintaining their shapes and motilities, while its dynamics in sperm cells is understood less than their non