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将原发性高血压患者44例随机分为两组,观察单独口服甲巯丙脯酸(CAP)和 CAP 与阿魏酸钠(SF)联合服用后肱动脉血压、尿中 TXB_2浓度及血中血管紧张素转化酶(ACE)活性的变化。结果表明,CAP 使原发性高血压患者血中 ACE 活性减低,有显著降压作用。但尿中 TXB_2排泄增加;SF 无降压作用,与 CAP 联合应用可使原发性高血压患者服用 CAP 后尿中 TXB_2排泄增加受到抑制,降压作用得到加强。
Forty-four patients with essential hypertension were randomly divided into two groups. The changes of brachial artery blood pressure, urinary TXB2 concentration and blood levels of captopril (CAP) and CAP combined with sodium ferulate (SF) Changes in angiotensin-converting enzyme (ACE) activity. The results show that, CAP in patients with essential hypertension reduce ACE activity in blood, there is a significant antihypertensive effect. However, urinary TXB_2 excretion increased; SF without antihypertensive effect, combined with CAP can make patients with essential hypertension TXB_2 excretion of urinary TXB 2 increased inhibition was suppressed, the antihypertensive effect was strengthened.